自律神經反應異常者(急性心理壓力後之復甦期副交感不升反降)其日後罹患胃潰瘍機率大增

Autonomic response to standardized stress predicts subsequent disease activity in ulcerative colitis.

Eur J Gastroenterol Hepatol. 2006; 18(4):413-20 (ISSN: 0954-691X)

Maunder RG; Greenberg GR; Nolan RP; Lancee WJ; Steinhart AH; Hunter JJ
Department of Psychiatry, Mount Sinai Hospital, Toronto, Canada. rmaunder@mtsinai.on.ca

OBJECTIVES: Prospective studies of the role of psychological stress in ulcerative colitis are inconsistent or show a modest relationship. We tested the hypothesis that individual differences in autonomic function are associated with differences in the disease course of ulcerative colitis. METHODS: The spectral power of heart rate variability, an indirect marker of autonomic function, was measured during a standardized stress protocol in 93 ulcerative colitis patients. Patients were categorized as typical or atypical by an increase or decrease, respectively, in the high frequency band of heart rate variability from a period of acute stress to recovery 5 min later. Disease activity was measured at baseline (time 1) and a second time point (time 2) 7-37 months later. RESULTS: An atypical pattern of heart rate variability at time 1, present in 29% of patients, was associated with lower mean disease activity at time 2 (atypical, 0.56+/-0.93; typical, 2.27+/-2.56, P=0.001). The contribution of heart rate variability pattern to explaining time 2 disease activity was independent of the contributions of other factors that differed between groups, including time 1 disease activity and lifetime corticosteroid use. DISCUSSION: An atypical pattern of autonomic reactivity may be a marker of individual differences in stress regulation that has prognostic significance in ulcerative colitis.