抽二手菸(家中或工作場所;每日超過2小時)的不良效應:心跳提高,HRV各參數(包括HRV, total power,LF,HF,LF/HF)均降低

Effects of passive smoking on heart rate variability, heart rate and blood pressure: an observational study.
Int J Epidemiol. 2007; 36(4):834-40 (ISSN: 0300-5771)
Felber Dietrich D; Schwartz J; Schindler C; Gaspoz JM; Barthélémy JC; Tschopp JM; Roche F; von Eckardstein A; Brändli O; Leuenberger P; Gold DR; Ackermann-Liebrich U;
Institute of Social and Preventive Medicine, University of Basel, Switzerland. denise.felber@unibas.ch

BACKGROUND: Exposure to environmental tobacco smoke (ETS) has been shown to increase the risk for cardiovascular diseases and death, and autonomic dysfunction (specifically, reduced heart rate variability (HRV)) is a predictor of increased cardiac risk. This study tests the hypothesis that ETS exposure reduces HRV in the general population and discusses possible pathways. METHODS: This cross-sectional study was conducted between 2001 and 2003 and is part of the SAPALDIA (Swiss Cohort Study on Air Pollution and Lung Diseases in Adults) study. The analysis included 1218 randomly selected non-smokers aged 50 and above who participated in 24-h electrocardiogram recordings. Other examinations included an interview, investigating health status (especially respiratory and cardiovascular health and health relevant behaviours and exposure to ETS) and measurements of blood pressure, body height and weight. RESULTS: Subjects exposed to ETS at home or at work for more than 2 h/day had a difference of -15% in total power (95%CI: -26 to -3%), low frequency power (-28 to -1%), low/high frequency ratio (-26 to -3%) and -18% (-29 to -4%) in ultralow frequency power of HRV compared with subjects not exposed to ETS at home or work. We also found a 2.7% (-0.01 to 5.34%) higher heart rate during the recording in exposed subjects. CONCLUSIONS: Exposure to ETS at home and work is associated with lower HRV and with higher heart rate in an ageing population. Our findings suggest that exposure to ETS increases cardiac risk through disturbances in the autonomic nervous system.