top of page

2010-01最新HRV臨床論文摘要 

正常幼童從平躺轉為60度上揚時其LF/HF會升高但具有癲癇症者則失去此功能

正常幼童從平躺轉為60度上揚時其LF/HF會升高但具有癲癇症者則失去此功能

Power spectrum analysis of heart rate variability in children with epilepsy





期刊

Child's Nervous System

出版社

Springer Berlin / Heidelberg

ISSN

0256-7040 (Print) 1433-0350 (Online)



Volume 17, Number 10 / 2001年10月

文章類目

Original Paper

DOI

10.1007/s003810100505



602-606

Subject Collection

醫學

SpringerLink Date

2004年2月19日












PDF (32.1 KB)HTMLFree PreviewFree Preview

摘要

Object: Children with epilepsy have been found to be at increased risk of death during childhood. Sudden unexpected death (SUDEP) has accounted for at least 12% of deaths of children with epilepsy. The exact mechanisms of SUDEP are unknown; however, theories suggested have, to date, focused on autonomic instability. The purpose of this study was to investigate autonomic function in children with chronic epilepsy by means of power spectrum analysis of heart rate variability. Methods: Thirty patients with epilepsy and 30 control subjects, all between the ages of 4 and 10 years, were enrolled in this study. Power spectrum analysis of heart rate variability (HRV) was performed under standardized conditions after the patients had rested for 15 min. Each patient was tested in a supine position first and then again in a head-up tilted position, with 15 min between the two tests. Results: There was no significant difference between the low-frequency component (LF) and the high-frequency component (HF) of heart rate variability, or the LF/HF ratio, between the study and control groups, whether the test subjects were in the supine or the head-up tilt position. In the control group, however, the subjects showed a significantly greater LF component and a smaller HF component of heart rate variability, and a greater LF/HF ratio in the head-up position than in the supine position. This implies a normal sympathovagal balance. This phenomenon was not observed in the study group. This implies that the modulating effects on autonomic function deriving from the hemisphere were probably disturbed, owing to the brain lesions that each of the study group patients had already sustained. Conclusions: A disturbed balance of activity between the sympathetic and parasympathetic nervous system might result from the loss of hemispheric influence in patients with epilepsy. Nevertheless, further investigation is clearly necessary to ascertain the possible association of this disturbed balance with SUDEP. Further investigation is also needed to establish the exact location of the region in the brain that gives rise to this modulating influence.



bottom of page